We report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking of 2D portraits and testing for association with inter-landmark distances. We detected significant associations (P-value <5þinspace×þinspace10−8) at 42 genome regions, nine of which have been previously reported. In follow-up analyses, 26 of the 33 novel regions replicate in East Asians, Europeans, or Africans, and one mouse homologous region influences craniofacial morphology in mice. The novel region in 1q32.3 shows introgression from Neanderthals and we find that the introgressed tract increases nasal height (consistent with the differentiation between Neanderthals and modern humans). Novel regions include candidate genes and genome regulatory elements previously implicated in craniofacial development, and show preferential transcription in cranial neural crest cells. The automated approach used here should simplify the collection of large study samples from across the world, facilitating a cosmopolitan characterization of the genetics of facial features.

Several research groups have shown that Generative Adversarial Networks (GANs) can generate photo-realistic images in recent years. Using the GANs, a map is created between a latent code and a photo-realistic image. This process can also be reversed: given a photo as input, it is possible to obtain the corresponding latent code. In this paper, we will show how the inversion process can be easily exploited to interpret the latent space and control the output of StyleGAN2, a GAN architecture capable of generating photo-realistic faces. From a biological perspective, facial features such as nose size depend on important genetic factors, and we explore the latent spaces that correspond to such biological features, including masculinity and eye colour. We show the results obtained by applying the proposed method to a set of photos extracted from the CelebA-HQ database. We quantify some of these measures by utilizing two landmarking protocols, and evaluate their robustness through statistical analysis. Finally we correlate these measures with the input parameters used to perturb the latent spaces along those interpretable directions. Our results contribute towards building the groundwork of using such GAN architecture in forensics to generate photo-realistic faces that satisfy certain biological attributes.